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dc.contributor.authorOgut, Selim
dc.contributor.authorKiziler, Ali Riza
dc.contributor.authorBahtiyar, Nurten
dc.contributor.authorGurol, Gonul
dc.contributor.authorAydemir, Birsen
dc.contributor.authorAKDEMİR, RAMAZAN
dc.contributor.authorVATAN, MEHMET BÜLENT
dc.contributor.authorCinemre, F. Behice
dc.contributor.authorCinemre, Hakan
dc.contributor.authorBuyukokuroglu, M. Emin
dc.date.accessioned2021-03-04T18:18:05Z
dc.date.available2021-03-04T18:18:05Z
dc.date.issued2015
dc.identifier.citationAydemir B., AKDEMİR R., VATAN M. B. , Cinemre F. B. , Cinemre H., Kiziler A. R. , Bahtiyar N., Buyukokuroglu M. E. , Gurol G., Ogut S., "The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture", BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.167, ss.179-186, 2015
dc.identifier.issn0163-4984
dc.identifier.othervv_1032021
dc.identifier.otherav_89f586ef-80e0-4f00-9bf4-2962099b87c2
dc.identifier.urihttp://hdl.handle.net/20.500.12627/93544
dc.identifier.urihttps://doi.org/10.1007/s12011-015-0307-6
dc.description.abstractChordae tendineae rupture process is associated with increased production of inflammatory and angiogenesis mediators in connective tissues, which contributes to chronic inflammation and pathogenesis of degenerative chordae. A few trace elements are known to possess antioxidant, anti-inflammatory, and antiangiogenic properties. Therefore, the aim of this study was to determine whether zinc, selenium, midkine (MK), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), vascular endothelial growth factor-A (VEGF-A), platelet-derived growth factor-BB (PDGF-BB), and reduced glutathione (GSH) levels are associated with inflammation and angiogenesis processes in the context of a potential etiology causing aggravation of mitral regurgitation and/or ruptured chordae tendineae. Seventy-one subjects comprising 34 patients with mitral chordae tendineae rupture (MCTR) and 37 healthy controls diagnosed on the basis of their clinical profile and transthoracic echocardiography were included in this study. The levels of GSH, MK, selenium, and zinc were found to be lower in the patients group when compared to control group. There were no significant difference in plasma TNF-alpha, IL-1 beta, IL-6, IL-8, VEGF-A, and PDGF-BB levels between two groups. There were positive significant correlations between MK and GSH, MK, and selenium levels in patients with MCTR. According to our data in which selenium, zinc, MK, and GSH decreased in MCTR patients, inflammatory response, oxidative stress, and trace element levels may contribute to etiopathogenesis of mitral regurgitation and/or ruptured chordae tendineae.
dc.language.isoeng
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectKlinik Tıp
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleThe Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture
dc.typeMakale
dc.relation.journalBIOLOGICAL TRACE ELEMENT RESEARCH
dc.contributor.departmentSakarya Üniversitesi , Tıp Fakültesi , Kardiyoloji Anabilim Dalı
dc.identifier.volume167
dc.identifier.issue2
dc.identifier.startpage179
dc.identifier.endpage186
dc.contributor.firstauthorID225178


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