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Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases

dc.contributor.authorSupuran, Claudiu T.
dc.contributor.authorElma, Pinar Eraslan
dc.contributor.authorKizilirmak, Merih
dc.contributor.authorGoktas, Fusun
dc.contributor.authorKarali, Nilgun
dc.contributor.authorAKDEMİR, ATİLLA
dc.contributor.authorAngeli, Andrea
dc.date.accessioned2021-03-04T19:10:58Z
dc.date.available2021-03-04T19:10:58Z
dc.date.issued2017
dc.identifier.citationKarali N., AKDEMİR A., Goktas F., Elma P. E. , Angeli A., Kizilirmak M., Supuran C. T. , "Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases", BIOORGANIC & MEDICINAL CHEMISTRY, cilt.25, ss.3714-3718, 2017
dc.identifier.issn0968-0896
dc.identifier.othervv_1032021
dc.identifier.otherav_8e812881-47c7-42eb-9799-346b731ec98d
dc.identifier.urihttp://hdl.handle.net/20.500.12627/96290
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2017.05.029
dc.description.abstractHuman carbonic anhydrases IX and XII are upregulated in many tumors and form a novel target for new generation anticancer drugs. Here we report the synthesis of novel 2-indolinone derivatives with the sulfonamide group as a zinc binding moiety. Enzyme inhibition assays confirmed that the compounds showed selectivity against hCA IX and XII over the widely distributed off-targets hCA I and II. Molecular modelling studies were performed to suggest modes of binding for these compounds. (C) 2017 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectBiyokimya
dc.subjectBiyoinorganik Kimya
dc.subjectTemel Bilimler
dc.subjectTemel Bilimler (SCI)
dc.subjectKİMYA, ORGANİK
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectKimya
dc.subjectKİMYA, TIP
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleNovel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases
dc.typeMakale
dc.relation.journalBIOORGANIC & MEDICINAL CHEMISTRY
dc.contributor.departmentBezmiâlem Vakıf Üniversitesi , Eczacılık Fakültesi , Farmakoloji Anabilim Dalı
dc.identifier.volume25
dc.identifier.issue14
dc.identifier.startpage3714
dc.identifier.endpage3718
dc.contributor.firstauthorID244130


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