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dc.contributor.authorSahin, Yesim Muge
dc.contributor.authorKuruca, Dürdane Serap
dc.contributor.authorErdemir, Gokce
dc.contributor.authorKABASAKAL, LEVENT
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorÇAM, MUHAMMET EMİN
dc.contributor.authorCesur, Sumeyye
dc.contributor.authorTAŞKIN, TURGUT
dc.date.accessioned2021-03-04T19:48:57Z
dc.date.available2021-03-04T19:48:57Z
dc.identifier.citationÇAM M. E. , Cesur S., TAŞKIN T., Erdemir G., Kuruca D. S. , Sahin Y. M. , KABASAKAL L., GÜNDÜZ O., "Fabrication, characterization and fibroblast proliferative activity of electrospun Achillea lycaonica-loaded nanofibrous mats", EUROPEAN POLYMER JOURNAL, cilt.120, 2019
dc.identifier.issn0014-3057
dc.identifier.othervv_1032021
dc.identifier.otherav_919a8a22-4465-4e5a-8f5a-12a60e116bca
dc.identifier.urihttp://hdl.handle.net/20.500.12627/98220
dc.identifier.urihttps://doi.org/10.1016/j.eurpolymj.2019.109239
dc.description.abstractThe use of natural compounds such as biocompatible and non-toxic plant extracts, without undesired side effects, in tissue engineering applications, is highly preferred compared to chemical drugs. In this study, the characterization and performance of electrospun Achillea lycaonica-loaded (0.125, 0.250 and 0.500, wt%) poly (lactic acid) (PLA) (8%, w/v) nanofibrous mats for skin tissue engineering were investigated. SEM, FTIR, DSC, and tensile strength test of the electrospun nanofibers have been investigated. Drug releasing test and cell culture study were also carried out. Achillea lycaonica-loaded nanofibrous mats in 0.250 (wt%) and 0.500 (wt%) demonstrated excellent cell compatibility and increased the viability of NIH/3T3 (mouse embryo fibroblast) cells within 72 h. According to the results, Achillea lycaonica-loaded PLA nanofibers have proper tensile strength and controlled release. The working temperature range enlarged for the composites having higher plant extract content. Consequently, Achillea lycaonica-loaded nanofibrous mats have a great potential in skin tissue engineering applications.
dc.language.isoeng
dc.subjectPolimer Karakterizasyonu
dc.subjectTemel Bilimler
dc.subjectFizikokimya
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectPOLİMER BİLİMİ
dc.titleFabrication, characterization and fibroblast proliferative activity of electrospun Achillea lycaonica-loaded nanofibrous mats
dc.typeMakale
dc.relation.journalEUROPEAN POLYMER JOURNAL
dc.contributor.departmentMarmara Üniversitesi , Eczacılık Fakültesi , Eczacılık Meslek Bilimleri Bölümü
dc.identifier.volume120
dc.contributor.firstauthorID15396


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